Many people love having a few cheeky drinks, and a few “cheeky” drinks basically means a LOT of drinks!

But waking up the next morning feeling rough after a big night out is never fun.

And sadly, it gets worse with age, for most of us the days of jumping out of bed after a heavy night feeling great and ready to face the day are long gone. Heck for me they were over by my mid-twenties!

So-called “hangover prevention pills” are becoming more and more popular nowadays as they promise to be the helping hand you need to make you feel better the next day.

While it’s not entirely possible to cure a hangover, they claim to reduce the severity of your symptoms.

But how?

Well, they usually contain a selection of natural ingredients which support your liver in metabolising alcohol as well as boosting antioxidant levels.

Nowadays, there are a lot of hangover prevention pills available on the market which can make choosing the best product difficult.

That’s why we’ve put together a list of the top products right now based on the ingredients, effectiveness and value for money.

Do hangover prevention pills work?

Alcohol causes hangovers in various different ways. Firstly, it inhibits the release of a hormone from your pituitary gland called vasopressin and this hormone helps your kidneys reabsorb water. That’s why drinking too much causes dehydration.

While dehydration plays a big part in hangovers, it isn’t the only cause.

Another major cause of hangovers is inflammation. When alcohol is metabolised in your liver, harmful waste products such as acetaldehyde are produced. These react with your cells causing inflammation.

And this is where hangover pills come into the picture, they can’t completely cure a hangover but can certainly lessen the symptoms associated with excessive alcohol consumption.

They include natural ingredients such as vitamins, minerals and herbal extracts that boost antioxidant levels to support your liver in neutralizing the harmful by-products of alcohol metabolism.

And that means you still need to take all the necessary hangover prevention precautions such as keeping well hydrated, eating before going out and, obviously, reducing your alcohol intake.

With the science out the way, let’s get straight into our pick of the best hangover prevention pills available right now.

7 Best Hangover Pills

In order to help you find good hangover pills in the sea of available options, we’ve researched and compared the best hangover pills below.

1) AfterDrink

A bottle AfterDrink pills

Our top spot goes to AfterDrink. That’s because AfterDrink has a well-balanced formulation and includes all the key ingredients such as Dihydromyricetin, B vitamins, Milk thistle, Prickly pear and many more. (We discuss the ingredients in more detail later in this article).

In fact, they include a total of 23 ingredients, all of which are natural. Unlike most supplements in this category, the dosing is clear and transparent as they don’t use a “proprietary blend”.

Overall, AfterDrink is high-quality product which is formulated to cover all angles when it comes to hangovers. That’s why it works well and has great reviews.

2) Hang Zero

A bottle of Hang Zero pills

Hang Zero is another great hangover pill with similar ingredients to AfterDrink. The downside is that the key ingredients are hidden behind a proprietary blend so it’s not exactly clear how much of each is included.

With that said, it’s a good entry-level product and is one of the cheaper options on the market. So it’s a sensible option if you’re on a budget.

3) Cheers

A bottle of Cheers pills

You may have seen Cheers on popular US TV show Shark Tank. Although they didn’t get investment at the time, they continued with their work and produced one of the most well-known products in the hangover pill category.

They also have the highest amount of Dihydromyricetin of all products currently on the market. It’s important to note that having the highest amount of Dihydromyricetin means that some of the other ingredients are underdosed to make space.

4) Purple Tree

A bottle of Purple Tree pills

Purple Tree hangover pills have come up the ranks in recent years. They have one of the cheapest products on the market so it’s great value for money.

They use willow bark as one of their ingredients which is a natural anti-inflammatory.

5) Flyby

A bottle of Flyby pills

Flyby is probably one of the most popular hangover pills on the market. If you take a closer look at the ingredients label, it’s exactly the same as Hang Zero’s.

The only difference is, Flyby is nearly twice as expensive. That’s the only reason it ranks lower in our list of top picks.

6) Drinkwel

A bottle of Drinkwell pills

Drinkwel is one of the first hangover pills to ever come on the market. Unlike the rest of the products on this list, it’s designed to be taken daily and is, therefore, more of a “liver health” supplement.

Furthermore, It comes with an expensive price tag and may not be for everyone’s budget.

7) Detoxx

A bottle of Detoxx pills

In similar fashion to Drinkwel, Detoxx is also one of the oldest hangover pills around. Although they don’t have Dihydromyricetin in their formulation, they still have a comprehensive list of things you’d want to see.

Being one of the first products on the market, they have a loyal customer base and strong company reputation.

What are the key hangover pill ingredients?

So, what are the key ingredients to look out for in hangover prevention pills and which ones actually work?

Despite the amount of alcohol-related research out there, only a few ingredients have been shown to reduce hangover symptoms in studies:

Dihydromyricetin (DHM)

DHM has been used as a hangover remedy in Asia for centuries. More recently, studies have shown that it speeds up alcohol metabolism and, therefore, has the potential to reduce hangover symptoms.(1)

B vitamins

B vitamins are essential for the metabolism of all the things we eat and drink. That includes alcohol. They are cofactors in the enzymatic reactions involved in the breakdown of alcohol. Hence, drinking can increase your requirements.(2)

Prickly pear

Prickly pear has been shown in studies to reduce hangover symptoms as well. That’s because it’s packed full of polyphenols which are antioxidants. The theory is that prickly pear helps settle inflammation caused by the free-radicals produced from drinking alcohol.(3)

Ginseng (Korean or Panax)

Korean red ginseng, also known as Panax ginseng, was shown in a small study to speed up alcohol metabolism and reduce hangover symptoms.(4)

Are there any side effects?

The products we’ve included in our list of best hangover pills are all made from natural ingredients. As dietary supplements, they are regarded as safe and there are no medicines or stimulants included.

With that said, everyone is different and could potentially experience side effects. Perhaps being intolerant or allergic to the herbal extracts that are included.

That’s why it’s important to read the ingredients label before taking any new supplements.


There you have it, our list of the best hangover prevention pills on the market right now.

The main thing to remember is that hangovers are caused by drinking too much alcohol. So the best thing for preventing a hangover is to limit your alcohol intake.

Hangover pills should be seen as a helping hand to your existing routine, rather than a cure.

With all that said, our favourite hangover pill and the best hangover cure we have found at WhiskeyBon is AfterDrink.